Output
Publications
Parmar, R., Burska, A., Emery, P., Mellado, M., Sacre, S. and Ponchel, F. (2014) 1.61 T-cells expressing TLR4 and CXCR4 are associated with an RA diagnostic in early inflammatory arthritis. Ann Rheum Dis, 73(1):A26-7.
Burska, A., Parmar, R., Emery, P., Melado, M., Sacre, S. and Ponchel, F. (2014) A1.3 Phenotyping B-cell may have value as RA diagnostic biomarker for patients with 12 months inflammatory arthritis. Ann Rheum Dis,73(1): A2.
Thwaites, R., Chamberlain, G. and Sacre, S. (2014) Emerging Role of Endosomal Toll-Like Receptors in Rheumatoid Arthritis. Front Immunol,5:1
2013 Critchley, H.D. and Harrison, N.A. (2013) Visceral influences on brain and behaviour. Neuron, 77(4): 624-638
Harrison, N.A., Cooper, E., Voon, V., Miles, K. and Critchley, H.D. (2013) Central autonomic network mediates cardiovascular responses to acute inflammation: Relevance to increased cardiovascular risk in depression? Brain Behav Immun, 31: 189-96
Alzabin, S., Kong, P., Medghalchi, M., Palfreeman, A., Williams, R. and Sacre, S. (2012) Investigation of the role of endosomal Toll-like receptors in murine collagen-induced arthritis reveals a potential role for TLR7 in disease maintenance. Arthritis ResTher, 14:R142
Clanchy, F. and Sacre, S. (2010) Modulation of TLR function has therapeutic potential in auto-immune disease. Exp Opin Biol Ther, 10(12):1703-16.
Sacre, S., Medghalchi, M., Gregory, B., Brennan, F. and Williams, R. (2010) The SSRIs fluoxetine and citalopram exhibit potent anti-inflammatory activity in human and murine models of rheumatoid arthritis and inhibit signalling via toll-like receptors. Arthritis Rheum, 62(3):683-93.
Midwood, K., Piccinini, A. and Sacre, S.M. (2009 ) Targeting toll-like receptors in autoimmunity. Curr Drug Targets, 10:1139-1155.
Harrison, N.A., Brydon, L., Walker, C., Gray, M.A., Steptoe, A. and Critchley, H.D. (2009) Inflammation causes mood changes through alterations in subgenual cingulate activity and mesolimbic connectivity. Biol Psychiatry, 66(5): 407-414
Harrison, N.A., Brydon, L., Walker, C., Gray, M.A., Steptoe, A., Dolan, R.J. and Critchley, H.D. (2009) Neural origins of human sickness in interoceptive responses to inflammation. Biol Psychiatry, 66(5): 415-422
Midwood, K., Sacre, S., Inglis, J., Trebaul, A., Chan, E., Piccinini, A.M., Drexler, S., Sofat, N., Kashiwagi, M., Orend, G., Brennan, F. and Foxwell, B. (2009) Tenascin-C is an endogenous activator of TLR4 that is essential for maintaining inflammation in arthritic joint disease. Nat. Med.15:774-80.
Sacre,S.M., Lo, A., Gregory, B., Simmonds, R., Williams, L., Feldmann, M., Brennan, F. and Foxwell, B.M. (2008) Inhibitors of toll-like receptor 8 reduce TNF production from human rheumatoid synovial membrane cultures. J Immunol, 181:8002-9.
Brydon, L., Harrison, N.A., Walker, C., Steptoe, S. and Critchley, H.D. (2008) Peripheral inflammation is associated with altered substantia nigra activity and psychomotor slowing in humans. Biol Psychiatry, 63(11): 1022-1029
Lundberg, A.M., Drexler. S.K., Monaco, C., Williams, L.M., Sacre, S.M., Feldmann, M. and Foxwell, B.M. (2007) Key differences in TLR3/poly I:C signalling and cytokine induction by human primary cells: a phenomenon absent from murine cell systems. Blood, 110(9):3245-52.
Sacre, S.M., Lundberg, A.M., Andreakos, E., Taylor, C., Feldmann, M. and Foxwell B.M. (2007) Selective use of TRAM in lipopolysaccharide (LPS) and lipoteichoic acid (LTA) induced NF-kappaB activation and cytokine production in primary human cells: TRAM is an adaptor for LPS and LTA signalling. J Immunol, 178(4):2148-54
Sacre,S.M., Andreakos, E., Kiriakidis, S., Amjadi, P., Lundberg, A., Giddins, G., Feldmann, M., Brennan, F. and Foxwell, B.M. (2007) The Toll-like receptor adaptor proteins MyD88 and Mal/TIRAP contribute to the inflammatory and destructive processes in a human model of rheumatoid arthritis. Am J. Pathol, 170(2): 518-25.
Sacre, S.M., Drexler, S.K., Andreakos, E., Feldmann, M., Brennan, F.M. and Foxwell, B.M. (2007) Could toll-like receptors provide a missing link in chronic inflammation in rheumatoid arthritis? Lessons from a study on human rheumatoid tissue. Ann Rheum Dis. 66(3): iii81-6.
Drexler, S.K., Sacre, S.M. and Foxwell, B.M. (2006) Toll-like receptors: a new target in rheumatoid arthritis? Exp Rev Clin Immun, 2(4): 585-599.
Sacre, S.M., Larche, M.J. and Foxwell, B.M. (2005) Pathogenic Role of TNFa in Rheumatoid Arthritis. Drug Discov Today: Dis Mech, 2: 367- 375.
Sacre, S.M., Andreakos, E., Taylor, P., Feldmann, M. and Foxwell, B.M. (2005) Molecular therapeutic targets in rheumatoid arthritis. Expert Rev Mol Med. 7:1-20.
Andreakos, E., Sacre, S., Foxwell, B.M. and Feldmann, M. (2005) The toll-like receptor-nuclear factor kB pathway in rheumatoid arthritis. Front Biosci,10: 2478-2488
Sacre, S.M., Andreakos, E., Feldmann, M. and Foxwell, B.M. (2004) Endotoxin signalling in human macrophages: Signalling via an alternate mechanism. J Endotoxin Res 10:445-52.
Andreakos, E., Sacre, S., Smith, C., Kiriakidis, S., Stonehouse, T., Lundberg, A., Feldmann, M. and Foxwell, B.M. (2004) Distinct Pathways of LPS-induced NF-kB activation and cytokine production in human myloid and non-myloid cells defined by selective utilization of MyD88 and Mal/TIRAP. Blood 103(6):2229-37
Feldmann, M., Andreakos, E., Smith, C., Bondeson, J., Yoshimura, S., Kiriakidis, S., Monaco, C., Gasparini, C., Sacre, S., Lundberg, A., Paleolog, E., Horwood, N.J., Brennan, F.M. and Foxwell, B.M. (2002) Is NF-kappaB a useful therapeutic target in rheumatoid arthritis? Ann Rheum Dis, 61 (2):ii13-8
Patterson, A.M., Siddall, H., Chamberlain, G., Gardner, L. and Middleton, J. (2002) Expression of the duffy antigen/receptor for chemokines (DARC) by the inflamed synovial endothelium. J Pathol, 197(1):108-16.
Book chapters
Sacre, S.M., Drexler, S. and Foxwell, B.M. (2005) Toll-like receptors and rheumatoid arthritis: is there a connection? In Toll-like Receptors in Inflammation. Eds: O'Neill L, Brint E. Birkhauser.
Andreakos, E., Udalova, I., Sacre, S. and Foxwell, B.M. (2003) The Role of NF-kB in Inflammatory Diseases. In Nuclear Factor Kb: Regulation and Role in Disease. Eds: Beyaert, R. Kluwer Acad. Publishers, Netherlands.
Patents
WO/2008/090331 - The use of SRIs to treat arthritis. Sandra Sacre and Brian Foxwell
WO/2008/090334 - Use of 5HT Receptor Antagonists for Treating Arthritis. Sandra Sacre and Brian Foxwel
WO/2009/019473 - Treatments for inflammatory arthritis. Sandra Sacre and Brian Foxwell